Characterisation of fasted state gastric and intestinal fluids collected from children

Fundamental knowledge about the composition of intestinal fluids in paediatric populations is currently unavailable. This study aimed to characterise gastric and fluid from populations. Gastric samples were obtained during routine clinical endoscopy patients at a large teaching hospital. These characterised measure pH; buffer capacity; osmolality; bile acid concentration composition. A total 55 children recruited aged 11 months 15 years age where 53 40 obtained. pH values recorded ranged 0.57 11.05 (median: 2.50) 0.89 8.97 3.27) fluids. The capacity did not change significantly between with median 12 mM/L/?pH for both osmolality 1 615 mOsm/kg, while 35 631 mOsm/kg. concentrations 0.002 2.3 mM value 0.017 whilst 0.0008 3.3 0.178 mM. Glycocholate; taurocholic acid; glycochenodeoxycholate taurochenodeoxycholate most commonly identified acids within All compositional components associated inter-individual variability. Further work required develop simulated media explore impact these on drug solubility dissolution.